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DW14800
$110 – $1,800
Products Details
Product Description
– DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity[1].
Web ID
– HY-128579
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C31H36N4O3
References
– [1]Zheng BN, et al. Targeting PRMT5 Activity Inhibits the Malignancy of Hepatocellular Carcinoma by Promoting the Transcription of HNF4α. Theranostics. 2019 Apr 13;9(9):2606-2617.
CAS Number
– 2243709-60-4
Molecular Weight
– 512.64
Compound Purity
– 99.63
SMILES
– CN(C)C1=CC=C(C(N2CCC(C=C(C(NCC(O)CN3CC(C=CC=C4)=C4CC3)=O)C=C5)=C5C2)=O)C=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Histone Methyltransferase
Isoform
– PRMT5
Pathway
– Epigenetics
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
