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Duocarmycin DM (free base)
SKU
HY-128915-10 mg
Category ADC Related
Tags ADC Cytotoxin;DNA Alkylator/Crosslinker, Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage, Cancer
$880 – $7,200
Products Details
Product Description
– Duocarmycin DM free base, a DNA minor-groove alkylator, is an antibody agent conjugates (ADCs) toxin. Duocarmycin DM free base is based on its characteristic curved indole structure and a spirocyclopropylcyclohexadienone electrophile to act anticancer activity[1][2].
Web ID
– HY-128915
Storage Temperature
– -20°C (Powder, protect from light, stored under nitrogen)
Shipping
– Blue Ice
Applications
– Cancer-programmed cell death
Molecular Formula
– C26H26ClN3O3
References
– [1]Patil PC, et al. A Short Review on the Synthetic Strategies of Duocarmycin Analogs that are Powerful DNA Alkylating Agents. Anticancer Agents Med Chem. 2015;15(5):616-630.|[2]Koch MF, et al. Structural, Biochemical, and Computational Studies Reveal the Mechanism of Selective Aldehyde Dehydrogenase 1A1 Inhibition by Cytotoxic Duocarmycin Analogues. Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13550-4.|[3]Chen KC, et al. Selective cancer therapy by extracellular activation of a highly potent glycosidic duocarmycin analogue. Mol Pharm. 2013;10(5):1773-1782.|[4]Chen KC, Schmuck K, Tietze LF, Roffler SR. Selective cancer therapy by extracellular activation of a highly potent glycosidic duocarmycin analogue. Mol Pharm. 2013;10(5):1773-1782.
CAS Number
– 1116745-06-2
Molecular Weight
– 463.96
Compound Purity
– 98.11
SMILES
– O=C(N1C[C@@H](CCl)C2=C1C=C(O)C3=CC=CC=C23)C(N4)=CC5=C4C=CC(OCCN(C)C)=C5
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– DMSO : 50 mg/mL (ultrasonic)
Target
– ADC Cytotoxin;DNA Alkylator/Crosslinker
Isoform
– Daunorubicins/Doxorubicins
Pathway
– Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
Product type
– ADC Related
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
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