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Products Details
Product Description
– Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD)[1][2].
Web ID
– HY-B0161
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C18H19NOS
Citations
– Neurosci Lett. 2022 Mar 16;773:136512.|Autism Res. 2021 Oct 3.|Neurotox Res. 2020 Dec;38(4):859-870.
References
– [1]De Berardis, D., et al., The effect of newer serotonin-noradrenalin antidepressants on cytokine production: a review of the current literature. Int J Immunopathol Pharmacol, 2010. 23(2): p. 417-22.|[2]Wang, S.Y., J. Calderon, and G. Kuo Wang, Block of neuronal Na+ channels by antidepressant duloxetine in a state-dependent manner. Anesthesiology, 2010. 113(3): p. 655-65.
CAS Number
– 116539-59-4
Molecular Weight
– 297.41
SMILES
– CNCC[C@H](OC1=CC=CC2=C1C=CC=C2)C3=CC=CS3
Clinical Information
– Launched
Research Area
– Neurological Disease; Cancer
Solubility
– 10 mM in DMSO
Target
– Serotonin Transporter
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
