Download Files:
Products Details
Product Description
– DualCathepsinL/JAK-IN-1 (Compound A8) serves as a dual inhibitor of Cathepsin L (CTSL) and JAK, exhibiting IC50 values of 0.68 μM for CTSL and 337.1 nM, 5.251 nM, 27.29 nM, and 172.6 nM for JAK1/2/3 and TYK2, respectively. This compound effectively prevents the activation of MAPK, NF-κB, and JAK/STAT signaling pathways, leading to significant anti-inflammatory therapeutic effects. DualCathepsinL/JAK-IN-1 is applicable in research on acute lung injury (ALI).
Web ID
– T205041
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C19H18ClN5
CAS Number
– 2450279-41-9
Molecular Weight
– C19H18ClN5
SMILES
– Cl.N1=CC=C(N=C1NC=2C=CC=C(N)C2)C3=CN(C=4C=CC=CC34)C
Target
– Others
Pathway
– MAPK|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic|||Stem Cells|||JAK/STAT signaling
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
1000 in stock
