Download Files:
Doxycycline hyclate
$50 – $72
Products Details
Product Description
– Doxycycline hyclate, an antibiotic, is an orally active and broad-spectrum metalloproteinase (MMP) inhibitor[1]. Doxycycline hyclate shows antibacterial activity and anti-cancer cell proliferation activity[1][2][3][4][5].
Web ID
– HY-N0565B
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture and light)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C22H24N2O8.1/2C2H6O.ClH.1/2H2O
Citations
– Adv Sci (Weinh). 2022 Jun 2;e2104823.|Biochem Biophys Res Commun. 6 August 2022.|bioRxiv. 2019 Apr.|Cell Death Dis. 2017 Mar 23;8(3):e2702.|Cell Death Dis. 2021 Apr 20;12(5):413.|Cell Rep. 2021 Jun 8;35(10):109225.|Cell Rep. 2021 Sep 21;36(12):109739.|Elife. 2021 Oct 27;10:e65759.|Food Funct. 16th November 2021.|Institute of Pharmacology and Toxicology University of Zürich. 2019 Nov.|J Biol Chem. 2022 Aug 12;102374.|J Biol Chem. 2023 Mar 17;104621.|J Genet Genomics. 2020 Nov 20;47(11):705-712.|Mol Cancer. 2020 Sep 9;19(1):139.|Patent. US 2019/0365645 A1.|Research Square Print. 2022 May.|Research Square Print. 2023 Mar 1.|STAR Protoc. 2021 Nov 5;2(4):100881.|STAR Protoc. 2021, 100548.|STAR Protoc. 2022 Apr 13;3(2):101296.|STAR Protoc. 2023 Feb 3;4(1):102092.|Theranostics. 2022 Jan 1;12(3):1187-1203.|Adv Sci (Weinh). 2021 Mar 15;8(10):2004344.|Ann Lab Med. 2021 May 1;41(3):293-301.|Biochem Biophys Res Commun. 30 July 2022.|Biomed Pharmacother. 2023 Jun 8;164:114998.|bioRxiv. 2023 Jun 14.|bioRxiv. 2023 Mar 31.|Cancer Biol Ther. 2022 Dec 31;23(1):328-335.|Cancer Res. 2023 Jul 18;CAN-23-0015.|Cell Commun Signal. 2022 Apr 12;20(1):52.|Cell Death Differ. 2023 Jun 15.|Cell Death Dis. 2020 May 7;11(5):331.|Cell Death Dis. 2022 Feb 10;13(2):138.|Cell Prolif. 2023 Aug 17;e13534.|Clin Exp Pharmacol Physiol. 2023 Apr 22.|FASEB J. 2020 Dec;34(12):16716-16735.|Front Cell Infect Microbiol. 28 April 2021.|Int J Mol Med. 2020 Apr;45(4):1187-1194.|iScience. 2023 Mar.|Katedra farmakologie a toxikologie. 2020 Jul.|Mol Cancer. 2020 Mar 30;19(1):68.|Molecules. 2023 Jul 26, 28(15), 5668.|Nat Microbiol. 2023 Mar;8(3):410-423.|NPJ Parkinsons Dis. 2022 Aug 6;8(1):100.|Redox Biol. 2023 Mar 21;62:102686.|Research Square Preprint. 2020 Jun.|Research Square Preprint. 2023 Jul 11.|Sci Adv. 2022 Jan 28;8(4):eabl5220.|Theranostics. 2022 Mar 28;12(7):3131-3149.|Virol Sin. 2022 May 12;S1995-820X(22)00081-5.|Water Res. 2023 May 21, 120110.|Cancer Lett. 2016 Jun 28;376(1):188-96.|Cell Death Differ. 2019 Nov;26(11):2400-2415. |Cell. 2023 Feb 2;186(3):591-606.e23.
References
– [1]Eusebio Manchado, et al. A combinatorial strategy for treating KRAS-mutant lung cancer. Nature. 2016 Jun 30;534(7609):647-51.|[2]Wilfried Briest, et al. Doxycycline ameliorates the susceptibility to aortic lesions in a mouse model for the vascular type of Ehlers-Danlos syndrome. J Pharmacol Exp Ther. 2011 Jun;337(3):621-7.|[3]Anna-Luisa Luger, et al. Doxycycline Impairs Mitochondrial Function and Protects Human Glioma Cells from Hypoxia-Induced Cell Death: Implications of Using Tet-Inducible Systems. Int J Mol Sci. 2018 May 17;19(5):1504.|[4]Ethan Ahler, et al. Doxycycline alters metabolism and proliferation of human cell lines. PLoS One. 2013 May 31;8(5):e64561.|[5]Le Zhang, et al. Doxycycline inhibits the cancer stem cell phenotype and epithelial-to-mesenchymal transition in breast cancer. Cell Cycle. 2017 Apr 18;16(8):737-745.
CAS Number
– 24390-14-5
Molecular Weight
– 512.94
Compound Purity
– 99.19
SMILES
– O=C(C(C1=O)=C(O)[C@@H](N(C)C)[C@]2([H])[C@@H](O)[C@]3([H])[C@@H](C)C4=C(C(C3=C(O)[C@@]21O)=O)C(O)=CC=C4)N.Cl.[0.5H2O].[0.5C2H6O]
Clinical Information
– Launched
Research Area
– Cancer; Infection
Solubility
– DMSO : 240 mg/mL (ultrasonic)|H2O : 125 mg/mL (ultrasonic)
Target
– Antibiotic;Bacterial;MMP;Parasite
Isoform
– Tetracycline
Pathway
– Anti-infection;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
