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DLin-KC2-DMA
$225 – $1,800
Products Details
Product Description
– DLin-KC2-DMA is an ionisable cationic lipid (pKa≈6) that is virtually non-toxic to antigen presenting cells (APCs). DLin-KC2-DMA produces significant siRNA-mediated gene silencing of GAPDH, when binds to lipid nanoparticles (LNP). DLin-KC2-DMA can be used in siRNA delivery studies[1][2].
Web ID
– HY-112758
Storage Temperature
– -20°C (Powder, stored under nitrogen)
Shipping
– Blue Ice
Molecular Formula
– C43H79NO2
References
– [1]Miller AD, et al. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013 Nov;10(6):781-811.|[2]Basha G, et al. Influence of cationic lipid composition on gene silencing properties of lipid nanoparticle formulations of siRNA in antigen-presenting cells. Mol Ther. 2011 Dec;19(12):2186-200.
CAS Number
– 1190197-97-7
Molecular Weight
– 642.09
Compound Purity
– 98.0
SMILES
– CCCCC/C=CC/C=CCCCCCCCCC1(CCCCCCCC/C=CC/C=CCCCCC)OC(CCN(C)C)CO1
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– DMSO : 100 mg/mL (ultrasonic)|Ethanol : 100 mg/mL (ultrasonic)
Target
– Liposome
Pathway
– Metabolic Enzyme/Protease
Product type
– Oligonucleotides
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
