DL-AP3

$25$140

Products Details

Product Description

– DL-AP3 is a competitive mGluR1 and mGluR5 antagonist. DL-AP3 is also an inhibitor of phosphoserine phosphatase. DL-AP3 has neuroprotective effect[1][2][3].

Web ID

– HY-100786

Storage Temperature

– -20°C (Powder, sealed storage, away from moisture)

Shipping

– Blue Ice

Applications

– Cancer-programmed cell death

Molecular Formula

– C3H8NO5P

References

– [1]Cui D, et al. DL-2-amino-3-phosphonopropionic acid protects primary neurons from oxygen-glucose deprivation induced injury. Bosn J Basic Med Sci. 2017 Feb 21;17(1):12-16. |[2]Hawkinson JE, et al. The metabotropic glutamate receptor antagonist L-2-amino-3-phosphonopropionic acid inhibits phosphoserine phosphatase. Eur J Pharmacol. 1996 Jun 27;307(2):219-25. |[3]Xu ZH, et al. Group I mGluR antagonist rescues the deficit of D1-induced LTP in a mouse model of fragile X syndrome. Mol Neurodegener. 2012 May 28;7:24. |[4]B.F. Kania, et al. Supraspinal basis of analgesic and clinical effects of the metabotropic glutamate mGluR1 antagonist during colonic distension in sheep. Small Ruminant Research. 2014. 117 (1).

CAS Number

– 5652-28-8

Molecular Weight

– 169.07

Compound Purity

– 98.0

SMILES

– NC(CP(O)(O)=O)C(O)=O

Clinical Information

– No Development Reported

Research Area

– Cancer; Neurological Disease

Solubility

– H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C)

Target

– Endogenous Metabolite;mGluR;Phosphatase

Isoform

– mGluR1;mGluR5

Pathway

– GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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