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Products Details
Product Description
– Dipyridamole-d16 is the deuterium labeled Dipyridamole. Dipyridamole (Persantine) is a phosphodiesterase inhibitor that blocks uptake and metabolism of adenosine by erythrocytes and vascular endothelial cells.
Web ID
– HY-B0312S1
Shipping
– Room temperature
Molecular Formula
– C24H24D16N8O4
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]Klabunde, R.E., Dipyridamole inhibition of adenosine metabolism in human blood. Eur J Pharmacol, 1983. 93(1-2): p. 21-6.|[3]Best, L.C., et al., Mode of action of dipyridamole on human platelets. Thromb Res, 1979. 16(3-4): p. 367-79.|[4]Aktas, B., et al., Dipyridamole enhances NO/cGMP-mediated vasodilator-stimulated phosphoprotein phosphorylation and signaling in human platelets: in vitro and in vivo/ex vivo studies. Stroke, 2003. 34(3): p. 764-9.
Molecular Weight
– 520.72
SMILES
– OC([2H])(C([2H])(N(C1=NC2=C(C(N3CCCCC3)=N1)N=C(N=C2N4CCCCC4)N(C([2H])(C([2H])(O)[2H])[2H])C([2H])(C([2H])(O)[2H])[2H])C([2H])(C([2H])(O)[2H])[2H])[2H])[2H]
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Phosphodiesterase (PDE)
Pathway
– Metabolic Enzyme/Protease
Product type
– Isotope-Labeled Compounds
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