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Products Details
Product Description
– Dideoxy-amanitin (compound 2), an α-Amanitin (HY-19610) derivative, is a potent and selective RNA polymerase II allosteric inhibitor with an IC50 value of 74.2 nM[1].
Web ID
– HY-148231
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C39H54N10O12S
References
– [1]Matinkhoo K, et, al. Design, Synthesis, and Biochemical Evaluation of Alpha-Amanitin Derivatives Containing Analogs of the trans-Hydroxyproline Residue for Potential Use in Antibody-Drug Conjugates. Chemistry. 2021 Jul 16;27(40):10282-10292.
CAS Number
– 58255-46-2
Molecular Weight
– 886.97
SMILES
– C[C@H]([C@H](NC([C@@H]1C[C@@H](O)CN1C([C@@H]2CC(N)=O)=O)=O)C(N[C@@H](CC3=C(SC[C@H](N4)C(N2)=O)NC5=C3C=CC=C5)C(NCC(N[C@H](C(NCC4=O)=O)[C@@H](C)CC)=O)=O)=O)[C@@H](O)CO
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– ADC Cytotoxin;DNA/RNA Synthesis
Pathway
– Antibody-drug Conjugate/ADC Related;Cell Cycle/DNA Damage
Product type
– ADC Related
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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