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Diclofenac (diethylamine)
$55 – $111
Products Details
Product Description
– Diclofenac diethylamine is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells[1], and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively[2]. Diclofenac diethylamine induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade[3].
Web ID
– HY-15036A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C18H22Cl2N2O2
Citations
– Pharm Res. 2022 Aug 24.|Biotechnol Bioeng. 2021 Sep 3.|Biotechnol Bioeng. 2021 Sep 3.|Chem-Biol Interact. 2021, 109425.|Chemosphere. 2019 Jun;225:378-387. |Eur J Drug Metab Pharmacokinet. 2022 Jun 22.|Institute of Chemistry, Federal University of Rio Grande do Sul (UFRGS). 2017 Nov.|Int J Mol Sci. 2022, 23(20), 12066.|J Hazard Mater. 2015 May 30;289:18-27.|J Pharmaceut Biomed. 2021, 114105.|J Phys Chem Solids. 2017 October;109:117-123.|Biotechnol Bioeng. 2021 Sep 3.|Phys Chem Chem Phys. 2016 Jan 21;18(3):1526-36. |Toxicol Mech Methods. 2019 Nov;29(9):654-664.
References
– [1]Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17.|[2]Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct;80:70-80.|[3]Chiho Kudo, et al. Diclofenac Inhibits Proliferation and Differentiation of Neural Stem Cells. Biochem Pharmacol. 2003 Jul 15;66(2):289-95.
CAS Number
– 78213-16-8
Molecular Weight
– 369.29
Compound Purity
– 99.96
SMILES
– O=C(O)CC1=CC=CC=C1NC2=C(Cl)C=CC=C2Cl.CCNCC
Clinical Information
– Launched
Research Area
– Inflammation/Immunology; Cancer
Solubility
– DMSO : 150 mg/mL (ultrasonic)
Target
– Apoptosis;COX
Isoform
– COX-1;COX-2
Pathway
– Apoptosis;Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
