Download Files:
DHODH-IN-8
$315
Only 1000 item(s) left in stock.
Products Details
Product Description
– DHODH-IN-8 (Compound 27) is an inhibitor of human and Plasmodium falciparum dihydroorotate dehydrogenase (DHODH) with IC50s of 0.13 μM and 47.4 μM, and Kis of 0.016 μM and 5.6 μM, respectively. DHODH-IN-8 has antimalarial activity[1].
Web ID
– HY-135666
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C17H13ClN2O2
References
– [1]Davies M, et al. Structure-based design, synthesis, and characterization of inhibitors of human and Plasmodium falciparum dihydroorotate dehydrogenases. J Med Chem. 2009 May 14;52(9):2683-93.
CAS Number
– 1148126-03-7
Molecular Weight
– 312.75
SMILES
– C/C(O)=C(C#N)/C(NC1=CC=C(C2=CC=CC=C2Cl)C=C1)=O
Clinical Information
– No Development Reported
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Dihydroorotate Dehydrogenase;DNA/RNA Synthesis;Parasite
Isoform
– Plasmodium
Pathway
– Anti-infection;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
