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Products Details
Product Description
– DFBTA is an orally active, potent and little brain penetrated ANO1 (Calcium-activated chloride channel anoctamin-1) inhibitor, with an IC50 of 24 nM. DFBTA shows analgesic efficacy for inflammatory pain[1].
Web ID
– HY-146334
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C18H10ClF2NO3S
References
– [1]Wang Y, et al. Optimization of 4-arylthiophene-3-carboxylic acid derivatives as inhibitors of ANO1: Lead optimization studies toward their analgesic efficacy for inflammatory pain. Eur J Med Chem. 2022 Jul 5;237:114413.
CAS Number
– 2966044-07-3
Molecular Weight
– 393.79
SMILES
– O=C(C1=C(SC=C1C2=CC=C(C=C2)Cl)NC(C3=C(C=CC(F)=C3)F)=O)O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Chloride Channel
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
