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Deucravacitinib
Price range: 102 CAD through 3,072 CAD
Products Details
Product Description
– Deucravacitinib (BMS-986165) is a highly selective, orally bioavailable, allosteric TYK2 inhibitor for the treatment of autoimmune diseases. It blocks receptor-mediated Tyk2 activation by stabilizing the regulatory JH2 domain, inhibiting IL-12/23 and type I IFN pathways. It selectively binds to the TYK2 pseudokinase (JH2) domain with an IC50 of 1.0 nM.
Web ID
– T14687
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C20H19D3N8O3
References
– Wrobleski ST, et al. Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J Med Chem. 2019 Jul 18.
CAS Number
– 1609392-27-9
Molecular Weight
– C20H19D3N8O3
Compound Purity
– 0.9942
SMILES
– [2H]C([2H])([2H])NC(=O)c1nnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC
Target
– Others
Pathway
– Immunology/Inflammation|||Stem Cells|||JAK/STAT signaling|||Angiogenesis|||Tyrosine Kinase/Adaptors|||Chromatin/Epigenetic
Product type
– Isotope products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
