Dasatinib
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Dasatinib

SKU T1448-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 59 CAD through 222 CAD

Products Details

Product Description

– Dasatinib (BMS-354825) is an orally active, ATP-competitive tyrosine kinase inhibitor that targets Src and Bcr-Abl (Ki=16/30 pM), with antitumor activity, used in the treatment of leukemia and lymphoma.

Web ID

– T1448

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C22H26ClN7O2S

Citations

– 1. Cai Z, Wu X, Song Z, et al.Metformin potentiates nephrotoxicity by promoting NETosis in response to renal ferroptosis.Cell Discovery.2023, 9(1): 104. 2. Yan H, Wu W, Hu Y, et al.Regorafenib inhibits EphA2 phosphorylation and leads to liver damage via the ERK/MDM2/p53 axis.Nature Communications.2023, 14(1): 2756. 3. Liu K, Hao Z, Zheng H, et al.Repurposing of rilpivirine for preventing platelet β3 integrin-dependent thrombosis by targeting c-Src active autophosphorylation.Thrombosis Research.2023 4. Cheng S, Jin P, Li H, et al. Evaluation of CML TKI Induced Cardiovascular Toxicity and Development of Potential Rescue Strategies in a Zebrafish Model. Frontiers in Pharmacology. 2021: 2866. 5. Wang T, Yang C, Li Z, et al.Flavonoid 4, 4′-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy.Redox Biology.2023: 103017. 6. Li F, Wang Z, Zheng D, et al.NK92 cells and peripheral blood NK cells respond oppositely upon dasatinib treatment.Immunology.2024 7. El Ouardi M, Tamarit L, Vayá I, et al.Cellular damage photosensitized by dasatinib, radical-mediated mechanisms and photoprotection in reconstructed epidermis.Free Radical Biology and Medicine.2024

References

– Chan CM, et al. Targeted inhibition of Src kinase with dasatinib blocks thyroid cancer growth and metastasis. Clin Cancer Res. 2012 Jul 1;18(13):3580-91.

CAS Number

– 302962-49-8

Molecular Weight

– C22H26ClN7O2S

Compound Purity

– 0.9989

SMILES

– N(C1=CC(N2CCN(CCO)CC2)=NC(C)=N1)C=3SC(C(NC4=C(C)C=CC=C4Cl)=O)=CN3

Target

– Others

Pathway

– Angiogenesis|||Apoptosis|||Autophagy|||Cytoskeletal Signaling|||Tyrosine Kinase/Adaptors

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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