Download Files:
DAPT
Price range: 85 CAD through 1,405 CAD
Products Details
Product Description
– DAPT (LY-374973) is a γ-secretase inhibitor that inhibits total Aβ and Aβ42 (IC50=115/200 nM) and is orally active. DAPT is also a Notch inhibitor. DAPT induces cell differentiation, autophagy and apoptosis.
Web ID
– T6202
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C23H26F2N2O4
Citations
– 1. Wang Z, Li W, Jing H, et al. Generation of hepatic spheroids using human hepatocyte-derived liver progenitor-like cells for hepatotoxicity screening. Theranostics. 2019, 9(22): 66902. Cai N, Xu B, Li X, et al. Roflumilast, a cyclic nucleotide phosphodiesterase 4 inhibitor, protects against cerebrovascular endothelial injury following cerebral ischemia/reperfusion by activating the Notch1/Hes1 pathway. European Journal of Pharmacology. 2022: 1750273. Huang C, Yan T, Xu Z, et al. Hypoxia Enhances Fusion of Oral Squamous Carcinoma Cells and Epithelial Cells Partly via the Epithelial–Mesenchymal Transition of Epithelial Cells. BioMed Research International. 2018 Feb 8;2018:50152034. Yang L, Wang X, Zhao G, et al.Leveraging temporal Wnt signal for efficient differentiation of intestinal stem cells in an organoid model.Stem Cells and Development.2023 (ja).5. Qu R, Peng Y, Zhou M, et al.MiR-223-3p attenuates M1 macrophage polarization via suppressing the Notch signaling pathway and NLRP3-mediated pyroptosis in experimental autoimmune uveitis.European Journal of Pharmacology.2023, 960: 176139.6. Zhan P, Lu Y, Lu J, et al.The activation of the Notch signaling pathway by UBE2C promotes the proliferation and metastasis of hepatocellular carcinoma.Scientific Reports.2024, 14(1): 22859.7. Xue J, Chu Y, Huang Y, et al.A tumorigenicity evaluation platform for cell therapies based on brain organoids.Translational Neurodegeneration.2024, 13(1): 53.8. Qin X, Fu L, Li C, et al.Optimized inner ear organoids for efficient hair cell generation and ototoxicity response modeling.Science China Life Sciences.2025: 1-15.
References
– Jiang LY, et al. γ-Secretase Inhibitor, DAPT Inhibits Self-renewal and Stemness Maintenance of Ovarian Cancer Stem-like Cells In Vitro. Chin J Cancer Res. 2011 Jun;23(2):140-6.
CAS Number
– 208255-80-5
Molecular Weight
– C23H26F2N2O4
Compound Purity
– 0.9981
SMILES
– C[C@H](NC(=O)Cc1cc(F)cc(F)c1)C(=O)N[C@H](C(=O)OC(C)(C)C)c1ccccc1
Pathway
– Autophagy|||Proteases/Proteasome|||Stem Cells|||Apoptosis|||Neuroscience
Product type
– Small Compound
New Class
– Top-SmallMol
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
1000 in stock
1000 in stock
