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Dapagliflozin ((2S)-1,2-propanediol, hydrate)
SKU
HY-10450A-10 mg
Category Reference compound
Tags Cancer; Metabolic Disease, Membrane Transporter/Ion Channel, SGLT
$55 – $154
Products Details
Product Description
– Dapagliflozin ((2S)-1,2-propanediol, hydrate) is the S-enantiomer of Dapagliflozin 1,2-propanediol, hydrate. Dapagliflozin ((2S)-1,2-propanediol, hydrate), a new type of agent used to treat diabetes mellitus (DM), is a competitive sodium/glucose cotransporter 2 (SGLT2) inhibitor, which results in excretion of glucose into the urine[1]. Dapagliflozin ((2S)-1,2-propanediol, hydrate) induces HIF1 expression and attenuates renal IR injury[2].
Web ID
– HY-10450A
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Metabolism-sugar/lipid metabolism
Molecular Formula
– C24H35ClO9
References
– [1]Pedersen MG, et al. Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells. Sci Rep. 2016 Aug 18;6:31214.|[2]Chang YK, et al. Dapagliflozin, SGLT2 Inhibitor, Attenuates Renal Ischemia-Reperfusion Injury. PLoS One. 2016 Jul 8;11(7):e0158810.|[3]Chiba Y, et al. Dapagliflozin, a Sodium-Glucose Co-Transporter 2 Inhibitor, Acutely Reduces Energy Expenditure in BAT via Neural Signals in Mice. PLoS One. 2016 Mar 10;11(3):e0150756.
CAS Number
– 960404-48-2
Molecular Weight
– 502.98
Compound Purity
– 99.99
SMILES
– O[C@H]1[C@H](C2=CC(CC3=CC=C(OCC)C=C3)=C(Cl)C=C2)O[C@H](CO)[C@@H](O)[C@@H]1O.C[C@H](O)CO.O
Clinical Information
– Launched
Research Area
– Cancer; Metabolic Disease
Solubility
– DMSO : ≥ 100 mg/mL|H2O : 2.38 mg/mL (ultrasonic)
Target
– SGLT
Isoform
– SGLT2
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
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