Products Details

Product Description

– Danshenol A, an abietane-type diterpenoid, is an aldose reductase (AR) inhibitor with an IC50 of 0.1 μM. Danshenol A can protect endothelial cells from oxidative stress by directly scavenging ROS. Danshenol A has anti-inflammatory and antitumor properties. Danshenol A can be used for atherosclerosis research[1][2][3][4].

Web ID

– HY-122917

Shipping

– Room temperature

Molecular Formula

– C21H20O4

References

– [1]Wenwen Zhao, et al. Danshenol A inhibits TNF-α-induced expression of intercellular adhesion molecule-1 (ICAM-1) mediated by NOX4 in endothelial cells. Sci Rep. 2017 Oct 11;7(1):12953. |[2]Kai Chen, et al. Danshenol A Alleviates Hypertension-Induced Cardiac Remodeling by Ameliorating Mitochondrial Dysfunction and Suppressing Reactive Oxygen Species Production. Oxid Med Cell Longev. 2019 Sep 11;2019:2580409. |[3]Y Tezuka, et al. Aldose reductase inhibitory constituents of the root of Salvia miltiorhiza Bunge. Chem Pharm Bull (Tokyo). 1997 Aug;45(8):1306-11.|[4]Gang Xu, et al. Two new abietane diterpenoids from Salvia yunnanensis. Planta Med. 2006 Jan;72(1):84-6.

CAS Number

– 189308-08-5

Molecular Weight

– 336.38

SMILES

– O=C1[C@@](CC(C)=O)(O)C2=C(C3=C1[C@@H](C)CO3)C=CC4=C2C=CC=C4C

Clinical Information

– No Development Reported

Research Area

– Cancer; Inflammation/Immunology; Cardiovascular Disease

Solubility

– 10 mM in DMSO

Target

– Aldose Reductase;Reactive Oxygen Species

Pathway

– Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB

Product type

– Natural Products

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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