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Cyclophosphamide
$60 – $168
Products Details
Product Description
– Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic activity, a immunosuppressant.
Web ID
– HY-17420
Storage Temperature
– 4°C (Powder, protect from light)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C7H15Cl2N2O2P
Citations
– ACS Appl Bio Mater. 2023 Sep 29.|Biochem Pharmacol. 2021 Jan;183:114340.|Biomed Res Int. 13 Jul 2022.|bioRxiv. 2023 Feb 27.|Breast Cancer Res Treat. 2023 May 19.|Cell Death Dis. 2020 Nov 12;11(11):976.|Evid Based Complement Alternat Med. 2021 Nov 11;2021:1718709.|Evid Based Complement Alternat Med. 2022 Feb 15;2022:7889199.|Int J Mol Sci. 2023, 24(4), 3818.|J Med Food. 2022 Jun 27.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|Life Sci. 2020 Aug 1;254:117590.|Mol Biol Cell. 2023 Mar 29;mbcE22110518.|Nat Commun. 2021 Jan 4;12(1):20.|Nat Commun. 2023 Apr 13;14(1):2109.|Open Life Sci. 2023, 18(1).|Phys Med Biol. 2020 Sep 24;65(19):195004.|Pulm Pharmacol Ther. 2023 Mar 9;102202.|Saudi J Biol Sci. 2023 Jun 15, 103707.|J Mol Med (Berl). 2019 Aug;97(8):1183-1193.|Research Square Preprint. 2023 Jul 10.
References
– [1]Schwartz PS, et al. Cyclophosphamide induces caspase 9-dependent apoptosis in 9L tumor cells. Mol Pharmacol. 2001 Dec;60(6):1268-1279.|[2]Harris RN, et al. Carbon tetrachloride-induced increase in the antitumor activity of cyclophosphamide in mice: a pharmacokineticstudy. Cancer Chemother Pharmacol. 1984;12(3):167-72.|[3]al-Jafari AA, et al. Inhibition of human acetylcholinesterase by cyclophosphamide. Toxicology. 1995 Jan 19;96(1):1-6.|[4]Liu P, et al. Administration of cyclophosphamide changes the immune profile of tumor-bearing mice. J Immunother. 2010 Jan;33(1):53-9.
CAS Number
– 50-18-0
Molecular Weight
– 261.09
Compound Purity
– 98.0
SMILES
– ClCCN(CCCl)P1(OCCCN1)=O
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– DMSO : ≥ 38 mg/mL|H2O : 33.33 mg/mL (ultrasonic)
Target
– DNA Alkylator/Crosslinker
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
