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Corticosterone
$50 – $70
Products Details
Product Description
– Corticosterone (17-Deoxycortisol) is an orally active and adrenal cortex-produced glucocorticoid, which plays an important role in regulating neuronal functions of the limbic system (including hippocampus, prefrontal cortex, and amygdala). Corticosterone increases the Rab-mediated AMPAR membrane traffic via SGK-induced phosphorylation of GDI. Corticosterone also interferes with the maturation of dendritic cells and shows a good immunosuppressive effect[1][2][3][4].
Web ID
– HY-B1618
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C21H30O4
References
– [1]Elftman MD, et al. Corticosterone impairs dendritic cell maturation and function. Immunology. 2007 Oct;122(2):279-90. |[2]Schaaf MJ, et al. Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone. Brain Res. 1998 Nov 30;813(1):112-20. |[3]Fahlke C, et al. Involvement of corticosterone in the modulation of ethanol consumption in the rat. Alcohol. 1994 May-Jun;11(3):195-202.
CAS Number
– 50-22-6
Molecular Weight
– 346.46
Compound Purity
– 99.70
SMILES
– C[C@@]12[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O
Clinical Information
– Phase 3
Research Area
– Endocrinology; Inflammation/Immunology; Neurological Disease
Solubility
– DMSO : 100 mg/mL (ultrasonic)|Ethanol : 14.29 mg/mL (ultrasonic)|H2O : 0.67 mg/mL (ultrasonic)
Target
– Endogenous Metabolite;Glucocorticoid Receptor;iGluR
Isoform
– AMPA Receptor;Human Endogenous Metabolite
Pathway
– Immunology/Inflammation;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling;Vitamin D Related/Nuclear Receptor
Product type
– Natural Products
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
