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Products Details
Product Description
– Clovoxamine (DU23811) (Compound 35) has binding affinity for serotonin transporter (SERT) (Ki: 61 nM). Clovoxamine is a 5-HT and norepinephrine reuptake (NE) re-uptake inhibitor. Clovoxamine is an antidepressant[1][2][3].
Web ID
– HY-129985
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C14H21ClN2O2
References
– [1]StaroÅ„ J, et al. Tuning the activity of known drugs via the introduction of halogen atoms, a case study of SERT ligands – Fluoxetine and fluvoxamine. Eur J Med Chem. 2021 Aug 5;220:113533.|[2]de Jong GJ. The use of a pre-column for the direct high-performance liquid chromatographic determination of the anti-depressants clovoxamine and fluvoxamine in plasma. J Chromatogr. 1980 Aug 8;183(2):203-11.|[3]Saletu B, et al. Clovoxamine and fluvoxamine-2 biogenic amine re-uptake inhibiting antidepressants: quantitative EEG, psychometric and pharmacokinetic studies in man. J Neural Transm. 1980;49(1-2):63-86.
CAS Number
– 54739-19-4
Molecular Weight
– 284.78
SMILES
– COCCCC/C(C1=CC=C(C=C1)Cl)=N/OCCN
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– 5-HT Receptor;Serotonin Transporter
Pathway
– GPCR/G Protein;Neuronal Signaling
Product type
– Reference compound
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