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Clopidogrel (hydrogen sulfate)
$66 – $106
Products Details
Product Description
– Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively[1]. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation[2]．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor[5].
Web ID
– HY-17459
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C16H18ClNO6S2
Citations
– ACS Omega. 2020 Aug 4;5(32):19995-20003.|Am J Transl Res. 2020 May 15;12(5):1741-1753.|Foods. 2023 Feb 10;12(4):777.|J Food Biochem. 2020 Sep;44(9):e13352.|ACS Nano. 2023 Mar 27.|Drug Des Devel Ther. 2020 Dec 21;14:5599-5610.|Front Pharmacol. 2022 Jan 10;12:792263.|Int J Biol Sci. 2019 Jan 1;15(1):239-252.|Int J Mol Sci. 2022, 23(16), 9118.|J Appl Physiol (1985). 2021 Sep 30.|J Pharm Health Care Sci. 2021 May 4;7(1):18.|Open Chem. 2020 Jun.|Research Square Preprint. 2023 Nov 14.|Theranostics. 2023; 13(6):2040-2056.|Thromb Res. 2023 May 8.
References
– [1]Katsunobu Hagihara, et al. Comparison of human cytochrome P450 inhibition by the thienopyridines prasugrel, Clopidogrel, and ticlopidine. Drug Metab Pharmacokinet. 2008;23(6):412-20.|[2]Jean-Marc Herbert, et al. P2Y12, a new platelet ADP receptor, target of Clopidogrel.Semin Vasc Med. 2003 May;3(2):113-22.|[3]Hai-Lu Wu, et al. Increased endoplasmic reticulum stress response is involved in Clopidogrel-induced apoptosis of gastric epithelial cells. PLoS One. 2013 Sep 13;8(9):e74381.|[4]Ran Ni, et al. Effect of Different Doses of Acetylsalicylic Acid on the Antithrombotic Activity of Clopidogrel in a Mouse Arterial Thrombosis Model.Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2338-2344.|[5]Kuszynski DS, et al. Clopidogrel treatment inhibits P2Y2-Mediated constriction in the rabbit middle cerebral artery [published online ahead of print, 2021 Oct 1]. Eur J Pharmacol. 2021;174545.
CAS Number
– 120202-66-6
Molecular Weight
– 419.90
Compound Purity
– 99.75
SMILES
– ClC1=C([C@@H](C(OC)=O)N2CCC3=C(C=CS3)C2)C=CC=C1.O=S(O)(O)=O
Clinical Information
– Launched
Research Area
– Cardiovascular Disease; Cancer
Solubility
– DMSO : ≥ 46.7 mg/mL|H2O : 16.67 mg/mL (ultrasonic)
Target
– Cytochrome P450;P2Y Receptor
Isoform
– CYP2;P2Y12 Receptor
Pathway
– GPCR/G Protein;Metabolic Enzyme/Protease
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
