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Clopidogrel (hydrogen sulfate)
$66 – $106
Products Details
Product Description
– Clopidogrel hydrogen sulfate is an antiplatelet agent to prevent blood clots. Clopidogrel hydrogen sulfate inhibits CYP2B6 and CYP2C19 with IC50s of 18.2 nM and 524 nM, respectively[1]. Clopidogrel hydrogen sulfate is a potent antithrombotic agent that inhibits ADP-induced platelet aggregation[2]．Clopidogrel hydrogen sulfate also is an orally active P2Y(12) inhibitor[5].
Web ID
– HY-17459
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C16H18ClNO6S2
Citations
– ACS Omega. 2020 Aug 4;5(32):19995-20003.|Am J Transl Res. 2020 May 15;12(5):1741-1753.|Foods. 2023 Feb 10;12(4):777.|J Food Biochem. 2020 Sep;44(9):e13352.|ACS Nano. 2023 Mar 27.|Drug Des Devel Ther. 2020 Dec 21;14:5599-5610.|Front Pharmacol. 2022 Jan 10;12:792263.|Int J Biol Sci. 2019 Jan 1;15(1):239-252.|Int J Mol Sci. 2022, 23(16), 9118.|J Appl Physiol (1985). 2021 Sep 30.|J Pharm Health Care Sci. 2021 May 4;7(1):18.|Open Chem. 2020 Jun.|Research Square Preprint. 2023 Nov 14.|Theranostics. 2023; 13(6):2040-2056.|Thromb Res. 2023 May 8.
References
– [1]Katsunobu Hagihara, et al. Comparison of human cytochrome P450 inhibition by the thienopyridines prasugrel, Clopidogrel, and ticlopidine. Drug Metab Pharmacokinet. 2008;23(6):412-20.|[2]Jean-Marc Herbert, et al. P2Y12, a new platelet ADP receptor, target of Clopidogrel.Semin Vasc Med. 2003 May;3(2):113-22.|[3]Hai-Lu Wu, et al. Increased endoplasmic reticulum stress response is involved in Clopidogrel-induced apoptosis of gastric epithelial cells. PLoS One. 2013 Sep 13;8(9):e74381.|[4]Ran Ni, et al. Effect of Different Doses of Acetylsalicylic Acid on the Antithrombotic Activity of Clopidogrel in a Mouse Arterial Thrombosis Model.Arterioscler Thromb Vasc Biol. 2018 Oct;38(10):2338-2344.|[5]Kuszynski DS, et al. Clopidogrel treatment inhibits P2Y2-Mediated constriction in the rabbit middle cerebral artery [published online ahead of print, 2021 Oct 1]. Eur J Pharmacol. 2021;174545.
CAS Number
– 120202-66-6
Molecular Weight
– 419.90
Compound Purity
– 99.75
SMILES
– ClC1=C([C@@H](C(OC)=O)N2CCC3=C(C=CS3)C2)C=CC=C1.O=S(O)(O)=O
Clinical Information
– Launched
Research Area
– Cardiovascular Disease; Cancer
Solubility
– DMSO : ≥ 46.7 mg/mL|H2O : 16.67 mg/mL (ultrasonic)
Target
– Cytochrome P450;P2Y Receptor
Isoform
– CYP2;P2Y12 Receptor
Pathway
– GPCR/G Protein;Metabolic Enzyme/Protease
Product type
– Reference compound
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