Products Details

Product Description

– Carbamazepine-d8 is the deuterium labeled Carbamazepine. Carbamazepine, a sodium channel blocker, is an anticonvulsant agent, with an IC50 of 131 μM[1][2].

Web ID

– HY-B0246S2

Shipping

– Room temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C15H4D8N2O

References

– [1]Willow, M. and W.A. Catterall, Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol Pharmacol, 1982. 22(3): p. 627-35.|[2]Okada, M., et al., Biphasic effects of carbamazepine on the dopaminergic system in rat striatum and hippocampus. Epilepsy Res, 1997. 28(2): p. 143-53.|[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

CAS Number

– 1538624-35-9

Molecular Weight

– 244.32

SMILES

– NC(N1C2=C([2H])C([2H])=C([2H])C=C2C([2H])=C([2H])C3=CC([2H])=C([2H])C([2H])=C31)=O

Clinical Information

– No Development Reported

Research Area

– Cancer; Neurological Disease

Solubility

– 10 mM in DMSO

Target

– Autophagy;Mitophagy;Sodium Channel

Pathway

– Autophagy;Membrane Transporter/Ion Channel

Product type

– Isotope-Labeled Compounds

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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