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Products Details
Product Description
– c-Met-IN-10 (compound 26a) is a highly potent c-Met kinase inhibitor with an IC50 value of 16 nM. c-Met-IN-10 has inhibitory activity against cancer cells A549, H460 and HT-29 with IC50s of 0.56 ~ 1.59 μM. c-Met-IN-10 suppresses the colony formation on HT-29 cells, induces HT-29 and A549 cells apoptosis, and inhibits A549 cells motility. c-Met-IN-10 can be used for researching anticancer[1].
Web ID
– HY-146274
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C26H21FN6O5
References
– [1]Liu J, et al. Design, synthesis and biological evaluation of novel N-[4-(2-fluorophenoxy)pyridin-2-yl]cyclopropanecarboxamide derivatives as potential c-Met kinase inhibitors. Eur J Med Chem. 2020;194:112244.
CAS Number
– 2415291-03-9
Molecular Weight
– 516.48
SMILES
– O=C(C1=NN(C(N(C1=O)C)=O)C2=CC=CC=C2)NC3=CC=C(C(F)=C3)OC4=CC(NC(C5CC5)=O)=NC=C4
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;c-Met/HGFR
Pathway
– Apoptosis;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
