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Product Description
– Bupivacaine-d99 is a deuterium labeled Bupivacaine. Bupivacaine is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain[1][2][3].
Web ID
– HY-B0405S
Shipping
– Room temperature
Molecular Formula
– C18H19D9N2O
References
– [1]Stoetzer C, et al. Inhibition of Voltage-Gated Na+ Channels by Bupivacaine Is Enhanced by the Adjuvants Buprenorphine, Ketamine, and Clonidine. Reg Anesth Pain Med. 2017;42(4):462-468.|[2]Schwoerer AP, et al. A Comparative Analysis of Bupivacaine and Ropivacaine Effects on Human Cardiac SCN5A Channels. Anesth Analg. 2015;120(6):1226-1234.|[3]Paganelli MA, et al. Actions of bupivacaine, a widely used local anesthetic, on NMDA receptor responses. J Neurosci. 2015;35(2):831-842.
CAS Number
– 474668-57-0
Molecular Weight
– 297.48
SMILES
– CC1=CC=CC(C)=C1NC(C2N(CCCC2)C([2H])(C([2H])(C([2H])(C([2H])([2H])[2H])[2H])[2H])[2H])=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Calcium Channel;iGluR;Isotope-Labeled Compounds;Potassium Channel;Sodium Channel
Isoform
– NMDA Receptor
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling;Others
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
