Download Files:
Bupivacaine
$60 – $90
Products Details
Product Description
– Bupivacaine is a NMDA receptor inhibitor. Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain[1][2][3].
Web ID
– HY-B0405
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C18H28N2O
Citations
– Nat Commun. 2023 Jun 3;14(1):3224.|Sci Rep. 2022 Jan 26;12(1):1378.|Stem Cell Res Ther. 2021 Feb 4;12(1):107.
References
– [1]Meaghan A Paganelli, et al. Actions of Bupivacaine, a widely used local anesthetic, on NMDA receptor responses. J Neurosci. 2015 Jan 14;35(2):831-42.|[2]Alexander P Schwoerer, et al. A Comparative Analysis of Bupivacaine and Ropivacaine Effects on Human Cardiac SCN5A Channels. Anesth Analg. 2015 Jun;120(6):1226-34.|[3]Carsten Stoetzer, et al. Inhibition of Voltage-Gated Na<sup>+</sup> Channels by Bupivacaine Is Enhanced by the Adjuvants Buprenorphine, Ketamine, and Clonidine. Reg Anesth Pain Med.Jul/Aug 2017;42(4):462-468.
CAS Number
– 38396-39-3
Molecular Weight
– 288.43
Compound Purity
– 99.96
SMILES
– O=C(C1N(CCCC)CCCC1)NC2=C(C)C=CC=C2C
Clinical Information
– Launched
Research Area
– Neurological Disease; Cancer
Solubility
– DMSO : 100 mg/mL (ultrasonic)
Target
– Calcium Channel;iGluR;Potassium Channel;Sodium Channel
Isoform
– NMDA Receptor
Pathway
– Membrane Transporter/Ion Channel;Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
