Download Files:
Brefeldin A
Price range: 54 CAD through 576 CAD
Products Details
Product Description
– Brefeldin A (Cyanein) belongs to the class of macrolide antibiotics and is an ATPase inhibitor (IC50=0.2 μM). Brefeldin A can induce tumor cell differentiation and apoptosis, and also possesses autophagy inhibitory activity.
Web ID
– T6062
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C16H24O4
Citations
– 1. Ma X, Zou F, Yu F, et al. Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses. Immunity. 2020, 53(6): 1315-1330. e9.
2. Luo Q, Liu Q, Cheng H, et al. Nondegradable ubiquitinated ATG9A organizes Golgi integrity and dynamics upon stresses. Cell reports. 2022, 40(7): 111195.
3. Bai R, Li L, Liu M, et al. Paper Based 3D Scaffold for Multiplexed Single Cell Secretomic Analysis. Analytical chemistry. 2018, 90(9): 5825-5832.
4. Yu T, Ling Q, Xu M, et al. ORF8 protein of SARS‐CoV‐2 reduces male fertility in mice. Journal of Medical Virology. 2022
5. Zhang X, Wu S, Liu J, et al.A Mosaic Nanoparticle Vaccine Elicits Potent Mucosal Immune Response with Significant Cross‐Protection Activity against Multiple SARS‐CoV‐2 Sublineages.Advanced Science.2023: 2301034.
6. He X, Zhang X, Wu B, et al.The receptor binding domain of SARS-CoV-2 Omicron subvariants targets Siglec-9 to decrease its immunogenicity by preventing macrophage phagocytosis.Nature Immunology.2024: 1-11.
7. Zhang H, You Y, Xu J, et al.New sesquiterpenes and viridin derivatives from Penicillium sp. Ameliorates NAFLD by regulating the PINK1/Parkin mitophagy pathway.Bioorganic Chemistry.2024: 107656.
8. Yang C, Ma Y, Lu Q, et al.2-Bromo-1, 4-Naphthalenedione promotes CD8+ T cell expansion and limits Th1/Th17 to mitigate experimental autoimmune encephalomyelitis.Journal of Neuroinflammation.2024, 21(1): 1-18.
9. Zhao X, Zhao Z, Li B, et al.ACSL4-mediated lipid rafts prevent membrane rupture and inhibit immunogenic cell death in melanoma.Cell Death & Disease.2024, 15(9): 695.
10. Wu K Y, Chen Y J, Lin S F, et al.Iron triggers Tv PI4P5K proteostasis and Arf-mediated cell membrane trafficking to regulate PIP2 signaling crucial for multiple pathogenic activities of the parasitic protozoan Trichomonas vaginalis.mBio.2024: e01864-24.
References
– Shao RG, et al. Brefeldin A is a potent inducer of apoptosis in human cancer cells independently of p53. Exp Cell Res. 1996 Sep 15;227(2):190-6.
CAS Number
– 20350-15-6
Molecular Weight
– C16H24O4
Compound Purity
– 0.999
SMILES
– [H][C@@]12C[C@H](O)C[C@@]1([H])[C@H](O)C=CC(=O)O[C@@H](C)CCCC=C2
Pathway
– DNA Damage/DNA Repair|||Autophagy|||Microbiology/Virology|||Membrane transporter/Ion channel
Product type
– Natural Product
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
1000 in stock
