BP-1-102
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BP-1-102

SKU T3708-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 53 CAD through 878 CAD

Products Details

Product Description

– BP-1-102 is an orally active, effective, and specific STAT3 inhibitor that binds Stat3 (Kd: 504 nM), blocks Stat3-phosphotyrosine (pTyr) peptide interactions and Stat3 activation (4-6.8 μM), and selectively inhibits the migration, survival, growth, and invasion of Stat3-dependent tumor cells. The BP-1-102-mediated inhibition of aberrantly active Stat3 in tumor cells suppresses the expression of [c-Myc, Bcl-xL, Cyclin D1, Survivin, and VEGF].

Web ID

– T3708

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C29H27F5N2O6S

Citations

– 1. Zhou B, Yan J, Guo L, et al. Hepatoma cell-intrinsic TLR9 activation induces immune escape through PD-L1 upregulation in hepatocellular carcinoma. Theranostics. 2020, 10(14): 6530. 2. He, Qiu‐Rui, et al. The natural product trienomycin A is a STAT3 pathway inhibitor that exhibits potent in vitro and in vivo efficacy against pancreatic cancer. British Journal of Pharmacology.  178.12 (2021): 2496-2515. 3. Chen C, Lu M, Lin S, et al. The nuclear gene rpl18 regulates erythroid maturation via JAK2-STAT3 signaling in zebrafish model of Diamond–Blackfan anemia. Cell Death & Disease. 2020, 11(2): 1-11 4. Yan J, Zhou B, Guo L, et al. GOLM1 upregulates expression of PD-L1 through EGFR/STAT3 pathway in hepatocellular carcinoma. American journal of cancer research. 2020, 10(11): 3705. 5. Strobel T D, Weber M, Heber N, et al.Revisiting the role of endogenous STAT3 in HPV‐positive cervical cancer cells.Journal of Medical Virology.2023, 95(11): e29230. 6. Zhang P, Wang X, Yang X, et al.Molecular control of PDPN hi macrophage subset induction by ADAP as a host defense in sepsis.JCI insight.2025

References

– Zhang X, et al. Proc Natl Acad Sci U S A. 2012, 109(24):9623-8.

CAS Number

– 1334493-07-0

Molecular Weight

– C29H27F5N2O6S

Compound Purity

– 0.9861

SMILES

– CN(CC(=O)N(Cc1ccc(cc1)C1CCCCC1)c1ccc(C(O)=O)c(O)c1)S(=O)(=O)c1c(F)c(F)c(F)c(F)c1F

Pathway

– JAK/STAT signaling|||Stem Cells

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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