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Products Details
Product Description
– BODIPY FL VH032 is a high-affinity VHL fluorescent probe (Kd= 3.01 nM) with application in time-resolved fluorescence resonance energy-transfer (TR-FRET) assays for high-throughput identification and characterization of VHL ligands. BODIPY FL VH032 consists of a derivative of von Hippel-Lindau (VHL) ligand VH 032 and a fluorophore BODIPY FL(with excitation peak at 504 nm and emission peak at 520 nm), joined by a polyethylene glycol (PEG) 4 linker. The BODIPY FL VH032 VHL TR-FRET signal is stable through the 90 – 300 min incubation time, and theTR-FRET binding assay is sensitive, selective and resistant to assay interference. BODIPY FL VH032 also exhibits high VHL affinity in a fluorescence polarization (FP) assay. Excitation maximum ~ 504 nm; emission maximum ~ 520 nm.
Web ID
– T41171
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C46H62BF2N7O9S
References
– Lin et al (2020) Development of BODIPY FL VH032 as a high-affinity and selective von Hippel-Lindau E3 ligase. ACS Omega 6 680 PMID: 33458521
CAS Number
– 2770675-66-4
Molecular Weight
– C46H62BF2N7O9S
SMILES
– O=C(N1[C@@H](CC(C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)[C@H](C(C)(C)C)NC(COCCOCCOCCOCCNC(CCC4=CC=C(C=C5C(C)=C6)N4[B-](F)(F)[N+]5=C6C)=O)=O
Product type
– Dye-Reagents
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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