Download Files:
Bleomycin (sulfate)
$108 – $672
Products Details
Product Description
– Bleomycin sulfate is a DNA synthesis inhibitor. Bleomycin hydrochloride is a DNA damaging agent. Bleomycin sulfate is an antitumor antibiotic[1].
Web ID
– HY-17565
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– N/A
Citations
– ACS Appl Mater Interfaces. 2019 Jan 16;11(2):1942-1950. |Biochem Biophys Res Commun. 2020 Jun 30;527(3):662-667.|Biochem Pharmacol. 2020 Apr;174:113846.|Biomed Pharmacother. September 2022, 113460.|Cell Death Dis. 2020 Jun 15;11(6):464.|Cell Death Dis. 2020 Nov 12;11(11):976.|Cells. 2021, 10(2), 202.|Cells. 2022 Dec 29;12(1):145.|Cells. 2023, 12(1), 145.|Chinese Journal of Plastic and Reconstructive Surgery. 23 December 2021.|Front Pharmacol. 2022 May 20;13:911945.|Fundamental Research. 23 December 2021.|Gene Rep. 2023 Jul 22, 101823.|Int Immunopharmacol. 2023 Jan 23;116:109723.|Int Immunopharmacol. 2023 Sep 15;124(Pt A):110905.|Mutat Res Genet Toxicol Environ Mutagen. 2016 Sep 15;808:27-37. |OncoImmunology. 2020 Sep 22;9(1):1824631.|Patent. US20190255042A1.|Patent. US20190282565A1.|Phytomedicine. 2023 Feb 11.|Research Square Preprint. 2023 Aug 30.|Research Square Preprint. 2023 Nov 23.|Research Square Print. November 28th, 2022.|Respir Res. 2020 Nov 2;21(1):290.|Respir Res. 2020 Feb 19;21(1):58. |Toxicol Lett. 2022 Apr 23;363:45-54.|Universidad de las Illes Balears. Facultad de Ciencias, 2022 Feb.|Am J Respir Cell Mol Biol. 2021 Apr 16.|Am J Respir Cell Mol Biol. 2021 Mar 24.|Am J Respir Cell Mol Biol. 2021 Oct 28.|Biomed Pharmacother. 2021, 111500.|Biomed Res Int. 2022 Feb 7;2022:8752325.|Cancer Lett. 2022 Feb 9;532:215588.|Cell Death Dis. 2020 Nov 13;11(11):978.|Cell Signal. 2021 Aug 4;110106.|Chin Med. 2023 May 24;18(1):60.|Clin Epigenetics. 2023 Nov 11;15(1):182.|Heliyon. 2023 Nov 13.|Immunopharmacol Immunotoxicol. 2020 Oct;42(5):436-444.|J Cell Biol. 2021 Feb 1;220(2):e201911025.|J Control Release. 2023 Aug;360:365-375.|Life Sci. 2021 Jan 1;264:118664.|Mediat Inflamm. 03 Mar 2022.|Mol Metab. 2022 Jun 2;101524.|Nat Metab. 2021 Dec 6.|Oxid Med Cell Longev. 01 Nov 2021.|Oxid Med Cell Longev. 30 Jun 2021.|Phytother Res. 2022 Jul 6.|Redox Biol. 2021 Jul 26;46:102082.|Research Square Preprint. 2023 Aug 4.|Sci China Life Sci. 2023 Jun 16.|Sci Rep. 2023 Jun 28;13(1):10485.|Small. 2021 Oct 8;e2103919.|Ther Adv Chronic Dis. 2020 Jul 30;11:2040622320940185.|Biomedicines. 2023, 11(2), 463.|BMC Pulm Med. 2023 Nov 13;23(1):440.|Cancer Lett. 2023 Feb 15;558:216092.|Front Biosci (Landmark Ed). 2023 Sep 22, 28(9), 209.|Inflammation. 2023 May 9.|Int Immunopharmacol. 2022, 113: 109409.|Int Immunopharmacol. 2023 May 22;120:110369.|Int J Biol Macromol. 2023 Apr 17;124476.|J Gene Med. 2022 Sep 30;e3451.|MedComm. 2023 Jul 12;4(4):e319.|Mol Med. 2023 Mar 14;29(1):32.|Molecules. 2023, 28(2), 753.|Nat Commun. 2022 Nov 17;13(1):7028.|Phytomedicine. 2023 Jun 17, 154919.|Research Square Preprint. 2023 Aug 3.|Transl Res. 2023 Feb 6;S1931-5244(23)00018-X.
References
– [1]Hovhannisyan G, et al. Comparative analysis of individual chromosome involvement in micronuclei induced by bleomycin in human leukocytes. Mol Cytogenet. 2016 Jun 21;9:49.|[2]Jaaskela-Saari HA, et al. Squamous cell cancer cell lines: sensitivity to bleomycin and suitability for animal xenograft studies. Acta Otolaryngol Suppl. 1997;529:241-4.|[3]Corboz MR, et al. Therapeutic administration of inhaled INS1009, a treprostinil prodrug formulation, inhibits bleomycin-induced pulmonary fibrosis in rats. Pulm Pharmacol Ther. 2018 Apr;49:95-103.|[4]Ling Peng, et al. Scutellarin ameliorates pulmonary fibrosis through inhibiting NF-κB/NLRP3-mediated epithelial-mesenchymal transition and inflammation. Cell Death Dis. 2020 Nov 13;11(11):978.|[5]Kang Miao, et al. Scutellarein inhibits BLM-mediated pulmonary fibrosis by affecting fibroblast differentiation, proliferation, and apoptosis. Ther Adv Chronic Dis. 2020 Jul 30;11:2040622320940185.
CAS Number
– 9041-93-4
Molecular Weight
– 1523 (average)
Compound Purity
– 99.49
SMILES
– O=C(C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C)N[C@H](C(N[C@H](C)[C@@H](O)[C@H](C)C(N[C@]([C@H](O)C)([H])C(NCCC2=NC(C3=NC(C(N[R])=O)=CS3)=CS2)=O)=O)=O)[C@H](C4=CN=CN4)O[C@H]5[C@H]([C@H]([C@@H]([C@@H](O5)CO)O)O)O[C@]6([H])[C@H]([C@H]([C@@H]([C@H](O6)CO)O)OC(N)=O)O.NC(NCCCC[R])=N.[R]CCC[S+](C)C.O=S(O)(O)=O.[R=].[Bleomycin A2].[R=].[Bleomycin B2]
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– DMSO : 41.67 mg/mL (ultrasonic)|H2O : 255 mg/mL (ultrasonic;warming)
Target
– Antibiotic;DNA/RNA Synthesis
Pathway
– Anti-infection;Cell Cycle/DNA Damage
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
