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Bis-ANS (dipotassium)
$185
Only 1000 item(s) left in stock.
Products Details
Product Description
– Bis-ANS dipotassium is a fluorescent probe of hydrophobic protein. Bis-ANS binds to tubulin with a Kd of 2 μM[1]. Bis-ANS dipotassium is a potent biphasic modulator of protein liquid-liquid phase separation (LLPS). Bis-ANS dipotassium promotes LLPS at low concentrations but suppresses LLPS at high concentrations[2].
Web ID
– HY-129811
Storage Temperature
– -20°C (Powder, sealed storage, away from moisture and light)
Shipping
– Blue Ice
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C32H22K2N2O6S2
References
– [1]P Horowitz, et al. Bis(1,8-anilinonaphthalenesulfonate). A novel and potent inhibitor of microtubule assembly. J Biol Chem. 1984 Dec 10;259(23):14647-50.|[2]W. Michael Babinchak, et al. Small molecules as potent biphasic modulators of protein liquid-liquid phase separation. Nature Communications volume 11, Article number: 5574 (2020)
CAS Number
– 65664-81-5
Molecular Weight
– 672.85
Compound Purity
– 99.0
SMILES
– O=S(C1=CC=CC2=C(C3=C4C=CC=C(S(=O)(O[K])=O)C4=C(NC5=CC=CC=C5)C=C3)C=CC(NC6=CC=CC=C6)=C12)(O[K])=O
Clinical Information
– No Development Reported
Research Area
– Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Microtubule/Tubulin
Pathway
– Cell Cycle/DNA Damage;Cytoskeleton
Product type
– Dye Reagents
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
