BI-D1870
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BI-D1870

SKU T6171-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 77 CAD through 2,320 CAD

Products Details

Product Description

– BI-D1870 is a highly specific, blood-brain-permeable, and ATP-competitive inhibitor of the N-terminal AGC kinase domain of RSK, with IC50 values ​​of 31 nM, 24 nM, 18 nM, and 15 nM for RSK1, RSK2, RSK3, and RSK4.

Web ID

– T6171

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C19H23F2N5O2

Citations

– 1. He S, Lu M, Zhang L, et al.RSK4 promotes the macrophage recruitment and M2 polarization in esophageal squamous cell carcinoma.Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease.2023: 166996.

References

– Sapkota GP, et al. BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo. Biochem J. 2007 Jan 1;401(1):29-38.

CAS Number

– 501437-28-1

Molecular Weight

– C19H23F2N5O2

Compound Purity

– 0.9943

SMILES

– CC(C)CCN1C(C)C(=O)N(C)c2cnc(Nc3cc(F)c(O)c(F)c3)nc12

Pathway

– MAPK|||Autophagy|||PI3K/Akt/mTOR signaling

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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