BI 2536
Add to CompareAdded to Compare

Download Files:

BI 2536

SKU T6173-1 mL * 10 mM (in DMSO) Category Brand:

Price range: 61 CAD through 1,416 CAD

Products Details

Product Description

– BI2536 is an effective Plk1 inhibitor (IC50: 0.83 nM). It has 4- and 11-fold greater selectivity than Plk2 and Plk3.

Web ID

– T6173

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C28H39N7O3

Citations

– 1. Zhang Y, Hong X, Hua S, et al. Reconstitution and mechanistic dissection of the human microtubule branching machinery. Journal of Cell Biology. 2022, 221(7): e202109053 2. Guo C, Zhu J, Wang J, et al. Neuroprotective effects of protocatechuic aldehyde through PLK2 /p-GSK3β/Nrf2 signaling pathway in both in vivo and in vitro models of Parkinson’s disease. Aging-us. 2019, 11 3. Han H W, Hahn S, Jeong H Y, et al. LINCS L1000 dataset-based repositioning of CGP-60474 as a highly potent anti-endotoxemic agent. Scientific Reports. 2018 Oct 8;8(1):14969 4. Wang D, Wang Y, Di X, et al.Cortical tension drug screen links mitotic spindle integrity to Rho pathway.Current Biology.2023 5. Kong Y, Liu Y, Li X, et al.Palmitoylation landscapes across human cancers reveal a role of palmitoylation in tumorigenesis.Journal of Translational Medicine.2023, 21(1): 1-19.

References

– Steegmaier M, et al. BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo. Current Biology (2007), 17(4), 316-322.

CAS Number

– 755038-02-9

Molecular Weight

– C28H39N7O3

Compound Purity

– 0.9988

SMILES

– C(C)[C@H]1N(C=2C(N(C)C1=O)=CN=C(NC3=C(OC)C=C(C(NC4CCN(C)CC4)=O)C=C3)N2)C5CCCC5

Pathway

– Apoptosis|||Chromatin/Epigenetic|||Cell Cycle/Checkpoint

Product type

– Small Compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

Related Products

Select options
Procainamide hydrochloride
Procainamide hydrochloride Price range: 50 CAD through 317 CAD
1 g1 mL * 10 mM (in DMSO)25 mg

1000 in stock

Select options
Mecarbinate
Mecarbinate Price range: 46 CAD through 56 CAD
1 g1 mL * 10 mM (in DMSO)

1000 in stock

Select options
Flubendazole
Flubendazole Price range: 53 CAD through 149 CAD
1 mL * 10 mM (in DMSO)100 mg50 mg

1000 in stock

Select options
7-Chloro-4-(piperazin-1-yl)quinoline
7-Chloro-4-(piperazin-1-yl)quinoline Price range: 56 CAD through 77 CAD
100 mg200 mg

1000 in stock

Select options
4-Methoxycoumarine
4-Methoxycoumarine Price range: 56 CAD through 266 CAD
1 g1 mL * 10 mM (in DMSO)50 mg

1000 in stock

My Cart
Wishlist
Recently Viewed
Categories

Request Data Sheet / Safty Data Sheet

Please enable JavaScript in your browser to complete this form.
=

Price Request

Please enable JavaScript in your browser to complete this form.
=

Compare Products (0 Products)
document.addEventListener('elementor/popup/show', function() { if (typeof turnstile !== 'undefined') { document.querySelectorAll('.cf-turnstile').forEach(function(el) { if (!el.dataset.rendered) { turnstile.render(el); el.dataset.rendered = true; } }); } });