Bergaptol

$264$290

Products Details

Product Description

– Bergaptol is an inhibitor of debenzylation of the CYP3A4 enzyme with an IC50 of 24.92 μM. Recent studies have shown that it has anti-proliferative and anti-cancer properties[1].

Web ID

– HY-76316

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Cancer-programmed cell death

Molecular Formula

– C11H6O4

References

– [1]Basavaraj Girennavar et al. Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit. Bioorganic & Medicinal Chemistry.June 2007, Pages 3684-3691|[2]Yucheng Zhao et al. Cloning, Functional Characterization, and Catalytic Mechanism of a Bergaptol O-Methyltransferase from Peucedanum praeruptorum Dunn. Front Plant Sci, 2016, 7: 722.|[3]Shen CY, et al. Bergaptol from blossoms of Citrus aurantium L. var. amara Engl inhibits LPS-induced inflammatory responses and ox-LDL-induced lipid deposition. Food Funct. 2020 Jun 24;11(6):4915-4926.|[4]Wu J, et al. Bergaptol Alleviates LPS-Induced Neuroinflammation, Neurological Damage and Cognitive Impairment via Regulating the JAK2/STAT3/p65 Pathway. J Inflamm Res. 2022 Nov 9;15:6199-6211.

CAS Number

– 486-60-2

Molecular Weight

– 202.16

Compound Purity

– 99.44

SMILES

– O=C1C=CC(C(O1)=C2)=C(O)C3=C2OC=C3

Clinical Information

– No Development Reported

Research Area

– Cancer; Inflammation/Immunology; Neurological Disease

Solubility

– DMSO : ≥ 50 mg/mL|H2O : 0.67 mg/mL (ultrasonic)

Target

– Cytochrome P450

Isoform

– CYP3

Pathway

– Metabolic Enzyme/Protease

Product type

– Natural Products

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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