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Baricitinib
$72 – $180
Products Details
Product Description
– Baricitinib (LY3009104; INCB028050) is a selective and orally bioavailable JAK1 and JAK2 inhibitor with IC50s of 5.9 nM and 5.7 nM, respectively.
Web ID
– HY-15315
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C16H17N7O2S
Citations
– Acta Pharmacol Sin. 2020 Aug 27. |Adv Sci (Weinh). 2020 Sep 24;7(21):2002518.|bioRxiv. 2018 Feb.|bioRxiv. 2020 Jun.|bioRxiv. 2020 Mar.|Cancer Res. 2021 Dec 15;81(24):6131-6141.|Cell. 2021 Apr 15;184(8):2167-2182.e22.|Chemrxiv. 2023 Aug 3.|Chemrxiv. Aug 11, 2021.|Diabetologia. 2023 Nov 4.|Heliyon. 2018 Nov 26;4(11):e00979. |Inflammation. 2021 Feb;44(1):206-216.|Institute of Natural Medicine,University of Toyama, Japan. 2018, Nov.|Int Immunopharmacol. 2022 Jul 15;110:109044.|Int J Obes (Lond). 2015 Nov;39(11):1607-18. |J Autoimmun. 2022 Feb;127:102793.|J Clin Invest. 2021 Dec 15;131(24):e145501.|J Immunol. 2013 Oct 1;191(7):3568-77. |Nat Commun. 2023 Apr 24;14(1):2342.|Platelets. 2021 Jun 7;1-12.|PLoS One. 2017 Jul 14;12(7):e0181126.|Rheumatology. 2023 Jan 17;kead013.|RSC Adv. 2018, 8, 21534-21540.|Sci Rep. 2022 May 12;12(1):7843.|Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.|Science. 2017 Dec 1;358(6367):eaan4368.|Signal Transduct Target Ther. 2021 Apr 24;6(1):165.|Toxicol Sci. 2020 Aug 1;176(2):410-422.|bioRxiv. 2020 Oct 5;2020.10.04.325415. |Commun Biol. 2021 Jun 2;4(1):654.|Research Square Preprint. 2020 Dec.
References
– [1]Fridman JS, et al. Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050. J Immunol. 2010 May 1;184(9):5298-307.|[2]Jabbari A, et al. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib. EBioMedicine. 2015 Feb 26;2(4):351-5.|[3]Khan IM, et al. Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration resistance. Int J Obes (Lond). 2015 Nov;39(11):1607-18.
CAS Number
– 1187594-09-7
Molecular Weight
– 371.42
Compound Purity
– 99.97
SMILES
– N#CCC1(N2N=CC(C3=C4C(NC=C4)=NC=N3)=C2)CN(S(=O)(CC)=O)C1
Clinical Information
– Launched
Research Area
– Inflammation/Immunology
Solubility
– DMSO : 25 mg/mL (ultrasonic;warming)
Target
– JAK
Isoform
– JAK1;JAK2;JAK3;Tyk2
Pathway
– Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
