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Baricitinib
Price range: 69 CAD through 525 CAD
Products Details
Product Description
– Baricitinib (INCB028050) is a JAK1 and JAK2 inhibitor (IC50=5.9/5.7 nM) with selective and oral activity. Baricitinib has potential anti-inflammatory, immunomodulatory and anti-tumor activity.
Web ID
– T2485
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C16H17N7O2S
Citations
– 1. Si H, Wang J, He R, et al. Identification of U937JAK3-M511I Acute Myeloid Leukemia Cells as a Sensitive Model to JAK3 Inhibitor. Frontiers in oncology. 2021, 11: 807200-807200.
2. Yao N, Tretter T, Kvacskay P, et al. Targeting of Janus Kinases Limits Pro-Inflammatory but Also Immunosuppressive Circuits in the Crosstalk between Synovial Fibroblasts and Lymphocytes. Biomedicines. 2021, 9(10): 1413.
3. Luschnig P, Kienzl M, Roula D, et al. The JAK1/2 inhibitor baricitinib suppresses eosinophil effector function and restricts allergen-induced airway eosinophilia. Biochemical Pharmacology. 2021: 114690.
4. Kvacskay P, Yao N, Schnotz J H, et al. Increase of aerobic glycolysis mediated by activated T helper cells drives synovial fibroblasts towards an inflammatory phenotype: new targets for therapy. Arthritis Research & Therapy. 2021 Feb 15;23(1):56. doi: 10.1186/s13075-021-02437-7.
5. Kvacskay P, Yao N, Schnotz J H, et al. Increase of aerobic glycolysis mediated by activated T helper cells drives synovial fibroblasts towards an inflammatory phenotype: new targets for therapy?. Arthritis Research & Therapy. 2021, 23(1): 1-15.
6. Development and evaluation of two whole-blood flow cytometry protocols for monitoring patients treated with JAK inhibitors
References
– Fridman JS, et al. J Immunol, 2010, 184(9), 5298-5307.
CAS Number
– 1187594-09-7
Molecular Weight
– C16H17N7O2S
Compound Purity
– 0.9997
SMILES
– CCS(=O)(=O)N1CC(CC#N)(C1)n1cc(cn1)-c1[nH]cnc2nccc12
Pathway
– Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling|||Cell Cycle/Checkpoint|||Chromatin/Epigenetic|||Stem Cells
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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