AZD3458

$250$2,650

Products Details

Product Description

– AZD3458 is a potent and remarkably selective PI3Kγ inhibitor with pIC50s of 9.1, 5.1, <4.5, and 6.5 for PI3Kγ, PI3Kα, PI3Kβ, and PI3Kδ, respectively[1].

Web ID

– HY-112443

Storage Temperature

– -20°C, 3 years; 4°C, 2 years (Powder)

Shipping

– Room Temperature

Applications

– Metabolism-sugar/lipid metabolism

Molecular Formula

– C20H23N3O4S2

References

– [1]Pemberton N, et al. Discovery of Highly Isoform Selective Orally Bioavailable Phosphoinositide 3-Kinase (PI3K)-γ Inhibitors. J Med Chem. 2018 Jun 28;61(12):5435-5441.

CAS Number

– 2132961-46-5

Molecular Weight

– 433.54

Compound Purity

– 99.82

SMILES

– O=C1N([C@@H](C)C2CC2)CC3=CC(C4=C(C)N=C(NC(C)=O)S4)=CC(S(=O)(C)=O)=C31

Clinical Information

– No Development Reported

Research Area

– Cancer; Metabolic Disease; Inflammation/Immunology

Solubility

– DMSO : 250 mg/mL (ultrasonic)

Target

– PI3K

Isoform

– PI3KC2α;PI3KC2β;PI3KC2γ;PI3KC3;PI3Kα;PI3Kβ;PI3Kγ;PI3Kδ

Pathway

– PI3K/Akt/mTOR

Product type

– Reference compound

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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