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Avosentan
$132 – $840
Web ID
– HY-15195
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C23H21N5O5S
References
– [1]Baltatu OC, Iliescu R, Zaugg CE, Reckelhoff JF, Louie P, Schumacher C, Campos LA.
Antidiuretic effects of the endothelin receptor antagonist avosentan.
Front Physiol. 2012;3:103.|[2]Konieczka K, Meyer P, Schoetzau A, Neutzner A, Mozaffarieh M, Flammer J.
Effect of avosentan (SPP-301) in porcine ciliary arteries.
Curr Eye Res. 2011 Feb;36(2):118-24.|[3]Mann JF, Green D, Jamerson K, Ruilope LM, Kuranoff SJ, Littke T, Viberti G; ASCEND Study Group.
J Am Soc Nephrol. 2010 Mar;21(3):527-35.|[4]Dieterle W, Hengelage T.
Absolute bioavailability and pharmacokinetics of avosentan in man.
Int J Clin Pharmacol Ther. 2009 Sep;47(9):587-94.|[5]Effect of SPP 301, an Endothelin Antagonist, on Intraocular Pressure in Glaucomatous Monkey Eyes By Wang, Rong-Fang; Podos, Steven M.; Serle, Janet B.; Baltatu, Ovidiu C. From Current Eye Research (2011), 36(1), 41-46.
CAS Number
– 290815-26-8
Molecular Weight
– 479.51
Compound Purity
– 98.54
SMILES
– COC1=C(OC(C(NS(C2=NC=C(C=C2)C)(=O)=O)=NC(C3=CC=NC=C3)=N4)=C4OC)C=CC=C1
Clinical Information
– Phase 3
Research Area
– Cardiovascular Disease; Endocrinology
Solubility
– DMSO : 6.67 mg/mL (ultrasonic)
Target
– Endothelin Receptor
Isoform
– ETA
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
