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Products Details
Product Description
– AUTAC2 is a FKBP12-targeting autophagy-mediated degrader (AUTAC). AUTAC2 contains an FBnG (p-Fluorobenzyl Guanine) and an SLF (c ligand of FKBP) moiety. SLF binds non-covalently to FKBP12[1].
Web ID
– HY-134184
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C61H81FN10O14S
References
– [1]Daiki Takahashi, et al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10.
CAS Number
– 2241669-08-7
Molecular Weight
– 1229.42
SMILES
– O=C([C@@H](NC(C)=O)CSC1=NC2=C(N=C(N)NC2=O)N1CC3=CC=C(F)C=C3)NCCCOCCOCCOCCCNC(CCC(NC4=CC=CC([C@@H](CCC5=CC=C(OC)C(OC)=C5)OC([C@@H]6CCCCN6C(C(C(C)(CC)C)=O)=O)=O)=C4)=O)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– AUTACs;Autophagy
Pathway
– Autophagy;PROTAC
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
