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Products Details
Product Description
– ATX inhibitor 15 (compound 30), a indole-based carbamate derivative, is a potent autotaxin (ATX) inhibitor with an IC50 of 2.17 nM. ATX inhibitor 15 inhibits in vivo ATX and the gene expression of pro-fibrotic factors. ATX inhibitor 15 has lung protection effects in Bleomycin challenged mice lung fibrosis model[1].
Web ID
– HY-143420
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C27H32ClN5O4S
References
– [1]Hongrui Lei, et al. Structural and PK-guided identification of indole-based non-acidic autotaxin (ATX) inhibitors exhibiting high in vivo anti-fibrosis efficacy in rodent model. Eur J Med Chem. 2022 Jan 5;227:113951.
CAS Number
– 2484811-52-9
Molecular Weight
– 558.09
SMILES
– O=C(NCC1=CC=C(C(Cl)=C1)OC)NC2=CN(CC)C3=C2C=C(C4=NC(CN(CCO)CCO)=CS4)C=C3
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Phosphodiesterase (PDE)
Isoform
– Autotaxin
Pathway
– Metabolic Enzyme/Protease
Product type
– Reference compound
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