Download Files:
Products Details
Product Description
– ATR-IN-20 is a potent ATR (ATM/ATR) inhibitor with an IC50 of 3 nM. ATR-IN-20 possess an inhibitory effect on mTOR (IC50 of 18 nM) while displaying good selectivity against PI3Kα (100 nM), ATM (100 nM), and DNA-PK (662 nM). ATR-IN-20 exhibits excellent pharmacokinetic profile (F = 30%), and has anticancer effects[1].
Web ID
– HY-151915
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C29H31N5O4S
References
– [1]Yinliang Qi, et al. Discovery of novel 7,7-dimethyl-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidines as ATR inhibitors based on structure-based drug design. Eur J Med Chem. 2022 Nov 26;246:114945.
Molecular Weight
– 545.65
SMILES
– O=C(N1C(C)(C)C2=NC(C3=CC=CC4=C3C=CN4)=NC(N5[C@H](C)COCC5)=C2C1)C6=CC=CC(S(=O)(C)=O)=C6
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– ATM/ATR;mTOR
Isoform
– ATM;ATR;mTOR
Pathway
– Cell Cycle/DNA Damage;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
