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AS2863619
Price range: 213 CAD through 2,288 CAD
Products Details
Product Description
– AS2863619 is an oral inhibitor of cyclin-dependent kinase 8 (CDK8) and CDK19. Inhibition of CDK8/19 can enhance the activation of STAT5, thereby activating the Foxp3 gene. It can convert antigen-specific effector/memory T cells into Foxp3+ regulatory T cells to study various immune diseases.
Web ID
– T8378
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C16H14Cl2N8O
References
– Akamatsu M, et al. Conversion of antigen-specific effector/memory T cells into Foxp3-expressing Treg cells by inhibition of CDK8/19. Sci Immunol. 2019 Oct 25;4(40). pii: eaaw2707.
CAS Number
– 2241300-51-4
Molecular Weight
– C16H14Cl2N8O
Compound Purity
– 1
SMILES
– Cl.Cl.Cc1nc2ccc(cc2[nH]1)-n1c(nc2cnccc12)-c1nonc1N
Pathway
– JAK/STAT signaling|||Cell Cycle/Checkpoint|||Stem Cells
Product type
– Small Compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
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