Download Files:
ARV-471
Price range: 298 CAD through 2,117 CAD
Products Details
Product Description
– Vepdegestrant (ARV-471) is an estrogen receptor (ER) α PROTAC molecule that degrades ER in ER-positive breast cancer cell lines with a DC50 of approximately 1 nM. It can reduce the expression of classically regulated ER target genes and inhibit the growth of ER-dependent cell lines (including those expressing ESR1 variants, such as Y537S and D538G) by degrading ER.
Web ID
– T39710
Storage Temperature
– -20℃
Shipping
– Blue Ice
Molecular Formula
– C45H49N5O4
Citations
– 1. Choi H I, Choi J, Kim J W, et al.Stability Evaluation and Pharmacokinetic Profiling of Vepdegestrant in Rodents Using Liquid Chromatography–Tandem Mass Spectrometry.Molecules.2024, 29(17): 4048.
References
– John J. Flanagan, et al. ARV-471, an oral estrogen receptor PROTAC™ protein degrader for breast cancer. American Association for Cancer Research.2019. 79 (4): P5-04-18.
CAS Number
– 2229711-68-4
Molecular Weight
– C45H49N5O4
Compound Purity
– 0.9993
SMILES
– OC=1C=C2C([C@H]([C@H](CC2)C3=CC=CC=C3)C4=CC=C(C=C4)N5CCC(CN6CCN(CC6)C=7C=C8C(=CC7)C(=O)N(C8)[C@@H]9C(=O)NC(=O)CC9)CC5)=CC1
Pathway
– Endocrinology/Hormones|||PROTAC
Product type
– PROTAC
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
Related Products
1000 in stock
1000 in stock
1000 in stock
