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ARD-1676
SKU
HY-156111-Get quote
Category Reference compound
Tags Androgen Receptor;PROTACs, Cancer, PROTAC;Vitamin D Related/Nuclear Receptor
Products Details
Product Description
– ARD-1676 is an orally available androgen receptor (AR) PROTAC degrader, consisting of AR ligand and cereblon ligand. ARD-1676 has AR-degrading activity in vitro and in vivo and inhibits VCaP tumor growth in mouse xenograft tumor models[1].
Web ID
– HY-156111
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C44H46ClN7O5
References
– [1]Xiang W, et al. Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR + Human Prostate Cancer. J Med Chem. 2023 Sep 8..
CAS Number
– 2632305-36-1
Molecular Weight
– 788.33
SMILES
– C[C@H]1CC2(CN1C3=CC=C(C(Cl)=C3)C#N)CCN(CC2)C4=CC=C(C=C4)C(N5CCC(CC5)CN6CC7=C(C6)C=C8C(N(C(C8=C7)=O)C9CCC(NC9=O)=O)=O)=O
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– Androgen Receptor;PROTACs
Pathway
– PROTAC;Vitamin D Related/Nuclear Receptor
Product type
– Reference compound
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