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Products Details
Product Description
– Apogossypolone (ApoG2) is an orally active Bcl-2 family proteins inhibitor with Ki values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-XL, respectively. Apogossypolone shows antitumor activities, induces cell apoptosis[1] and autophagy[2]. Apogossypolone also has antifungal activity[3].
Web ID
– HY-19551
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C28H26O8
References
– [1]Cheng P, et al. The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular carcinoma [corrected] cells. Cell Death Dis. 2013 Feb 7;4(2):e489.|[2]Yuan Sun, et al. Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. Cancer Biol Ther. 2008 Sep;7(9):1418-26. |[3]Jay E Mellon, et al. Inhibitory effects of gossypol, gossypolone, and apogossypolone on a collection of economically important filamentous fungi. J Agric Food Chem. 2012 Mar 14;60(10):2740-5.
CAS Number
– 886578-07-0
Molecular Weight
– 490.50
SMILES
– O=C1C(C(C2=O)=C(C)C(C3=C2C=C(O)C(O)=C3C(C)C)=O)=C(C)C(C4=C1C=C(O)C(O)=C4C(C)C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Autophagy;Bcl-2 Family;Fungal;ROS Kinase
Isoform
– Bcl-2;Bcl-xL;Mcl-1
Pathway
– Anti-infection;Apoptosis;Autophagy;Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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