Download Files:
AP14145 (hydrochloride)
$742
Only 1000 item(s) left in stock.
Products Details
Product Description
– AP14145 hydrochloride is a potent KCa2 (SK) channel negative allosteric modulator with an IC50 of 1.1 μM for KCa2.2 (SK2) and KCa2.3 (SK3) channels. AP14145 hydrochloride inhibition strongly depends on two amino acids, S508 and A533 in the channel. AP14145 hydrochloride prolonged atrial effective refractory period (AERP) in rats and demonstrates antiarrhythmic effects in a Vernakalant-resistant porcine model of atrial fibrillation (AF)[1][2].
Web ID
– HY-120355A
Shipping
– Room temperature
Applications
– Neuroscience-Neuromodulation
Molecular Formula
– C18H18ClF3N4O
References
– [1]Rafel Simó-Vicens, et al. A New Negative Allosteric Modulator, AP14145, for the Study of Small Conductance Calcium-Activated Potassium (K<sub>Ca</sub>2) Channels. Br J Pharmacol. 2017 Dec;174(23):4396-4408.|[2]Jonas Goldin Diness, et al. Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca<sup>2+</sup>-Activated K <sup>+</sup> Channels in Pigs. Circ Arrhythm Electrophysiol. 2017 Oct;10(10):e005125.
CAS Number
– 2387505-59-9
Molecular Weight
– 398.81
SMILES
– CC(NC1=C2C(N=C(N[C@@H](C3=CC=CC(C(F)(F)F)=C3)C)N2)=CC=C1)=O.[H]Cl
Clinical Information
– No Development Reported
Research Area
– Cardiovascular Disease
Solubility
– 10 mM in DMSO
Target
– Potassium Channel
Pathway
– Membrane Transporter/Ion Channel
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
