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Anisomycin
$42 – $198
Products Details
Product Description
– Anisomycin is a potent protein synthesis inhibitor which interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system[1]. Anisomycin is a JNK activator, which increases phospho-JNK[2][3]. Anisomycin is a bacterial antibiotic[4].
Web ID
– HY-18982
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C14H19NO4
References
– [1]Synthesis Marina MacÃas-Silva, et al. Anisomycin is a Multifunctional Drug: More than Just a Tool to Inhibit Protein. Current Chemical Biology, 2010, 4, 124-132.|[2]Gao X, et al. Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKIIδ expression in the aged atrium. Cardiovasc Res. 2018 Apr 1;114(5):737-746.|[3]Lu Z, et al. Colistin-induced autophagy and apoptosis involves the JNK-Bcl2-Bax signaling pathway and JNK-p53-ROS positive feedback loop in PC-12 cells.|[4]Zhengle Tang, et al. In vivo toxicological evaluation of Anisomycin. Toxicol Lett. 2012 Jan 5;208(1):1-11.
CAS Number
– 22862-76-6
Molecular Weight
– 265.31
Compound Purity
– 99.44
SMILES
– O[C@@H]1[C@@H](OC(C)=O)[C@@H](CC2=CC=C(OC)C=C2)NC1
Clinical Information
– No Development Reported
Research Area
– Cancer; Infection
Solubility
– DMSO : ≥ 50 mg/mL|H2O : 4 mg/mL (ultrasonic;warming;heat to 60°C)
Target
– Antibiotic;Apoptosis;Bacterial;DNA/RNA Synthesis;JNK;Parasite
Isoform
– JNK
Pathway
– Anti-infection;Apoptosis;Cell Cycle/DNA Damage;MAPK/ERK Pathway
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
