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Product Description
– Amantadine-d6 is the deuterium labeled Amantadine[1]. Amantadine (1-Adamantanamine) is an orally avtive and potent antiviral agent with activity against influenza A viruses. Amantadine inhibits several ion channels such as NMDA and M2, and also inhibits Coronavirus ion channels. Amantadine also has anti-orthopoxvirus and anticancer activity. Amantadine can be used for Parkinson’s disease, postoperative cognitive dysfunction (POCD) and COVID-19 research[2][3][4][5][6][7].
Web ID
– HY-B0402S1
Shipping
– Room temperature
Applications
– COVID-19-anti-virus
Molecular Formula
– C10H11D6N
References
– [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Suzuki H, et al. Emergence of amantadine-resistant influenza A viruses: epidemiological study. J Infect Chemother. 2003;9(3):195-200.|[3]Hubsher G, et al. Amantadine: the journey from fighting flu to treating Parkinson disease. Neurology. 201278(14):1096-1099.|[4]Donald F Smee, et al. A review of compounds exhibiting anti-orthopoxvirus activity in animal models. Antiviral Res. 2003 Jan57(1-2):41-52. |[5]Fink K, et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses. 2021 Mar 2413(4):539. |[6]Zhang J, et al. Amantadine alleviates postoperative cognitive dysfunction possibly by increasing glial cell line-derived neurotrophic factor in rats. Anesthesiology. 2014 Oct121(4):773-85.|[7]Lan Z, et al. Amantadine inhibits cellular proliferation and induces the apoptosis of hepatocellular cancer cells in vitro. Int J Mol Med. 201536(3):904-910.
CAS Number
– 1219805-53-4
Molecular Weight
– 157.29
SMILES
– NC12C([2H])(C3CC(C2([2H])[2H])CC(C1([2H])[2H])C3)[2H]
Clinical Information
– No Development Reported
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Bcl-2 Family;CDK;Influenza Virus;Orthopoxvirus;SARS-CoV
Pathway
– Anti-infection;Apoptosis;Cell Cycle/DNA Damage
Product type
– Isotope-Labeled Compounds
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
