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Products Details
Product Description
– AHR antagonist 5 hemimaleate, a potent and orally active aryl hydrocarbon receptor (AHR) antagonist, has an IC50 of < 0.5 µΜ. AHR antagonist 5 hemimaleate significantly inhibits tumor growth combined with checkpoint inhibitor anti-PD-1 (WO2018195397, example 39)[1].
Web ID
– HY-136220A
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C27H26O2FN7
References
– [1]Alfredo C. Castro, et al. Indole ahr inhibitors and uses thereof. WO2018195397A2.
Molecular Weight
– 499.55
SMILES
– CC(C1=C2N(N=C1)C(N[C@H]3CC(C4=CC=CC=C4N5)=C5CC3)=NC(C6=CN=CC(F)=C6)=N2)C.O=C(O)/C=CC(O)=O.[1/2]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Aryl Hydrocarbon Receptor
Pathway
– Immunology/Inflammation
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
