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Products Details
Product Description
– AChE-IN-20 (compound M26) is a potent AChE inhibitor with IC50 value of 397.32 nM and with Ki value of 335.76 nM. AChE-IN-20 shows inhibition potency against hCA I , hCA II and α-GLY with IC50 values of 84.14, 69.24 and 52.08 nM and with Ki values of 97.86, 76.23 and 57.93 nM, respectively[1].
Web ID
– HY-147952
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C22H20N8O6S2
References
– [1]Lolak N, et al. Synthesis, characterization, inhibition effects, and molecular docking studies as acetylcholinesterase, α-glycosidase, and carbonic anhydrase inhibitors of novel benzenesulfonamides incorporating 1,3,5-triazine structural motifs. Bioorg Chem. 2020 Jul;100:103897.
CAS Number
– 2428389-65-3
Molecular Weight
– 556.57
SMILES
– O=C(C1=CC=C(NC2=NC(NC3=CC=C(S(=O)(N)=O)C=C3)=NC(NC4=CC=C(S(=O)(N)=O)C=C4)=N2)C=C1)O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology; Neurological Disease
Solubility
– 10 mM in DMSO
Target
– Cholinesterase (ChE)
Isoform
– AChE
Pathway
– Neuronal Signaling
Product type
– Reference compound
Disclaimer: All products are for research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation.
