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Ac-YVAD-cmk

SKU HY-16990-1 mg Category Reference compound Tags Apoptosis, Caspase, Inflammation/Immunology

$80 – $450

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Products Details

Product Description

– Ac-YVAD-cmk (Caspase-1 Inhibitor II) is a selective caspase-1 (IL-1beta converting enzyme, ICE)) inhibitor with neuroprotective and anti-inflammatory effects. Ac-YVAD-cmk effectively suppresses the expression of IL-1β and IL-18. Ac-YVAD-cmk inhibits pyroptosis in many diseases[1][2].

Web ID

– HY-16990

Storage Temperature

– -20°C (Powder, sealed storage, away from moisture and light)

Shipping

– Blue Ice

Applications

– COVID-19-immunoregulation

Molecular Formula

– C24H33ClN4O8

References

– [1]Wang F, et al. Alcohol accumulation promotes esophagitis via pyroptosis activation. Int J Biol Sci. 2018;14(10):1245-1255. Published 2018 Jul 13. |[2]Liang H, et al. Ac-YVAD-cmk improves neurological function by inhibiting caspase-1-mediated inflammatory response in the intracerebral hemorrhage of rats. Int Immunopharmacol. 2019;75:105771. |[3]Mathiak G, et al. Caspase-1-inhibitor ac-YVAD-cmk reduces LPS-lethality in rats without affecting haematology or cytokine responses. Br J Pharmacol. 2000;131(3):383-386.

CAS Number

– 178603-78-6

Molecular Weight

– 540.99

Compound Purity

– 97.41

SMILES

– OC1=CC=C(C[C@H](NC(C)=O)C(N[C@H](C(N[C@@H](C)C(N[C@@H](CC(O)=O)C(CCl)=O)=O)=O)C(C)C)=O)C=C1

Clinical Information

– No Development Reported

Research Area

– Inflammation/Immunology

Solubility

– DMSO : 100 mg/mL (ultrasonic)

Target

– Caspase

Isoform

– Caspase 1

Pathway

– Apoptosis

Product type

– Reference compound

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.