A947
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A947

SKU T74686-1 mg Category Brand:

Price range: 1,712 CAD through 5,656 CAD

Products Details

Product Description

– A947 is a potent and selective SMARCA2 protein hydrolysis-targeted chimeric molecule (PROTAC) that induces the degradation of SMARCA2 by binding to VHL E3 ubiquitin ligase, with significant antitumor activity in vivo and in vitro, especially in SMARCA4-mutant non-small cell lung cancer (NSCLC) cells.

Web ID

– T74686

Storage Temperature

– -20℃

Shipping

– Blue Ice

Molecular Formula

– C61H76N12O7S

CAS Number

– 2378056-80-3

Molecular Weight

– C61H76N12O7S

Compound Purity

– 0.9884

SMILES

– O(C1=CC(N2C3CN(CC2CC3)C=4C=C(N=NC4N)C5=C(O)C=CC=C5)=CC=N1)[C@H]6C[C@H](OC7CCN(CC8CCN(CC8)C=9C=C([C@H](C(=O)N%10[C@H](C(N[C@@H](C)C%11=CC=C(C=C%11)C=%12SC=NC%12C)=O)C[C@@H](O)C%10)C(C)C)ON9)CC7)C6

Pathway

– PROTAC|||Chromatin/Epigenetic

Product type

– PROTAC

Booklet

Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.

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